SPRAVATO® (Esketamine) Therapy in Texas & Colorado
Spravato Patient Testimonials
These are real patients or caregivers of patients with treatment-resistant depression.
They have been compensated for their time by Janssen Pharmaceuticals, Inc.
Nicole's Story
Ben's Story
Allison's Caregiver Story
Amy's Story
Grace's Story
Sally's Story
A REMS-Certified Treatment for Depression
Klarisana offers FDA-approved SPRAVATO® (esketamine) therapy for adults struggling with Treatment-Resistant Depression (TRD), Major Depressive Disorder with Suicidal Ideation (MDDSI). As a REMS-certified provider, we ensure that every patient receives care in a safe, supervised setting—fully compliant with federal guidelines.
What Is SPRAVATO®?
SPRAVATO is a nasal spray formulation of esketamine, derived from ketamine and approved for use in patients who haven’t found relief with traditional antidepressants. Administered in-clinic only under strict observation, SPRAVATO can produce rapid improvements in mood and symptoms.
Is Spravato ketamine?
Yes. Ketamine exists as a mixture of two mirror-image molecules, known as the S- and R-enantiomers. SPRAVATO contains only the purified S-enantiomer (esketamine), which is FDA-approved for treatment-resistant depression and administered as a nasal spray.
How Does SPRAVATO Work?
SPRAVATO targets NMDA receptors in the brain, triggering increased neural connectivity and rapid antidepressant effects. Unlike SSRIs, which can take weeks, SPRAVATO may begin to work within hours or days.
How long does Spravato last?
Many patients experience improvements that last days to weeks, especially when paired with psychotherapy.
What is ketamine nasal spray used for?
SPRAVATO is used to treat treatment-resistant depression and depression with suicidal thoughts in adults.
SPRAVATO REMS: Why In-Clinic Treatment Matters
SPRAVATO is not available for home use. It must be administered in a REMS-certified clinic like Klarisana to ensure:
- Monitoring for side effects (dissociation, blood pressure changes)
- Proper dosing and medical supervision
- Patient safety during and after treatment
Looking for “Spravato near me” or “Spravato clinics”?
All Klarisana locations are certified and approved for in-clinic administration.
Steps in the SPRAVATO Treatment Process
- Initial Evaluation — Assess medical history and treatment eligibility
- Insurance Review — We confirm coverage or explore patient assistance options
- Treatment Phase — SPRAVATO administered in-clinic 2x/week for 4 weeks
- Monitoring — You stay on-site for 2+ hours under supervision
- Maintenance — Frequency is gradually reduced to fit your care plan
What to do after Spravato treatment?
You must have someone drive you home, and we provide post-treatment tips to ensure comfort and safety.
Cost, Insurance, and Patient Assistance
We help patients navigate common coverage questions, such as:
- Is Spravato® covered by insurance or Medicaid?
- Does Blue Cross Blue Shield cover Spravato®?
- How much does Spravato® cost with or without insurance?
- Is esketamine covered by Medicaid?
Our team understands that figuring out insurance can be overwhelming, especially when it comes to mental health treatments. Spravato® is covered by most major insurance providers, including many Blue Cross Blue Shield and Colorado Medicaid plans. We’re here to walk you through every step of the process—verifying your benefits, handling authorizations, and helping you understand any out-of-pocket costs.
Need help?
We also assist with enrollment in Spravato withMe, Janssen’s patient support program for cost savings and care navigation.
SPRAVATO withMe and Other Resources
Spravato withMe helps eligible patients:
- Verify insurance benefits
- Access co-pay savings (if qualified)
- Get reminders and educational support
What is Spravato withMe?
It’s a free support program from Janssen Pharmaceuticals, designed to help you start and stay on treatment.
FAQ
What is Spravato
SPRAVATO® is a prescription medicine used with or without an antidepressant taken by mouth, to treat adults with treatment-resistant depression (TRD) with an antidepressant taken by mouth, to treat depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions.
Spravato dosage and dose schedule
Typically, sessions occur twice a week initially, then adjust based on individual response and provider guidance.
Most patients will start with a 56mg dose of Spravato, and increase to 84mg dosing by the second session
Once in the maintenance phase, if it is determined to be appropriate, patients can move back down to the 56mg dose
What is the Spravato success rate and outcomes?
Clinical trials show that SPRAVATO® can be highly effective for treatment-resistant depression. In one Phase 3 study, 69.3% of patients receiving SPRAVATO plus an oral antidepressant responded (with a 50% or greater reduction in depression scores), compared to 52% for placebo. Remission rates were 52.5% for SPRAVATO versus 31% for placebo. More recent data from the ESCAPE-TRD study also found that patients were 1.5 times more likely to achieve remission at 8 weeks when using SPRAVATO compared to quetiapine XR.
Who makes Spravato?
Janssen, a division of Johnson & Johnson
Is Spravato REMS-certified?
Only if administered at REMS-approved clinics
Am I a Candidate for SPRAVATO® Therapy?
SPRAVATO® is typically recommended for adults who have not experienced sufficient relief from traditional antidepressants—whether for treatment‑resistant depression or major depressive disorder with suicidal thoughts. Our expert team will evaluate your medical history, current treatments, and overall health to determine if SPRAVATO® is the right option for you.
Will my insurance cover Spravato® therapy?
Many insurance plans, including certain Medicaid programs, cover Spravato®. Our staff can help verify your coverage.
What can I expect during a Spravato® session?
You’ll self-administer the nasal spray under medical supervision in our comfortable clinic. We’ll monitor you for about two hours to ensure safety.
Does Blue Cross Blue Shield cover Spravato®?
Many Blue Cross Blue Shield plans do cover Spravato® therapy. Coverage can vary by state and plan, but our team is happy to verify your benefits. Most major insurance providers may offer coverage for Spravato® if you meet the medical criteria.
Does Medicaid cover Spravato®?
Some Medicaid programs do cover Spravato®, depending on the state and your specific plan. Our staff can help you confirm your eligibility. In general, most major insurance providers—including Medicaid in some cases—may cover Spravato® treatment with prior authorization.
What can I expect during a Spravato® session?
You’ll self-administer the nasal spray under medical supervision in our comfortable clinic. We’ll monitor you for about two hours to ensure safety.
Still Have Questions?
Schedule a Free Consultation!
Find a SPRAVATO Clinic Near You
Klarisana provides Spravato treatment at certified locations across Texas and Colorado. Click below to learn more:
Ready to Start Feeling Better?
If you’re struggling with depression that hasn’t improved with traditional treatment, SPRAVATO may offer a new path forward. Our team is here to support you with compassion, clarity, and clinical expertise.
Contact us to schedule your consultation and take the next step toward healing
