Is Ketamine a Psychedelic? Understanding the Science Behind Psychedelic Therapy
The term “psychedelic” can carry a lot of weight—and a lot of misconceptions. For some, it conjures images of spiritual journeys or colorful hallucinations. For others, it’s associated with mental health breakthroughs and transformative healing. At Klarisana, we’re committed to clearing up the confusion and presenting the science clearly and responsibly—especially when it comes to questions like: Is ketamine a psychedelic? And what does it mean to work with a psychedelic therapist?
What Does “Psychedelic” Really Mean?
The word “psychedelic” comes from Greek roots meaning “mind manifesting.” Scientifically, psychedelics are substances that alter perception, mood, and cognitive processes by interacting with specific receptors in the brain—usually serotonin receptors like 5-HT2A. Classic psychedelics include psilocybin (found in certain mushrooms), LSD, and DMT.
However, not all substances that create altered states are chemically similar to classic psychedelics. This is where ketamine comes in.
So, Is Ketamine a Psychedelic?
The short answer: Yes—but not in the traditional sense.
Ketamine is classified as a dissociative anesthetic. It works primarily on the brain’s glutamate system by acting on NMDA receptors, rather than the serotonin system like traditional psychedelics.
Despite this difference, ketamine can produce altered states of consciousness, changes in perception, and a sense of detachment from one’s usual thought patterns—effects that are often described as “psychedelic.” Many patients report feelings of expanded awareness, emotional release, or seeing things from a completely new perspective.
Ketamine, Spravato®, and Other Treatment Options
At Klarisana, we offer both ketamine therapy or (KAP) and Spravato® (esketamine)—a nasal spray that is FDA-approved for treatment-resistant depression and administered in a clinical setting. Like ketamine, Spravato® can have dissociative and psychedelic-like effects, though the intensity and experience can vary.
We also recognize that psychedelic-like therapy is not for everyone. That’s why our services include non-altering treatments such as talk therapy and medication management. Whether someone is seeking deep psychological processing, ongoing integration work, or traditional mental health support, we have a range of options to meet each individual’s unique needs.
What Is a Psychedelic Therapist?
A psychedelic therapist is a licensed mental health professional trained to support individuals before, during, and after psychedelic experiences—whether with ketamine or other compounds. At Klarisana, our therapists are specifically trained in integration and trauma-informed care. They help patients make meaning of their experiences, reconnect with their inner resilience, and stay anchored throughout the process.
Addressing the Controversy Around Psychedelics
Much of the controversy surrounding psychedelics comes from decades of stigma, misinformation, and recreational misuse. However, recent research has reignited interest in the therapeutic potential of psychedelics, including ketamine, psilocybin, and MDMA.
We believe it’s important to separate hype from hope. At Klarisana, we take a medical approach to psychedelic therapy—offering treatments that are evidence-based, ethical, and closely supervised by trained professionals. We respect the power of these tools and ensure that every experience is supported by clinical structure and psychological care.
So, is ketamine a psychedelic? Scientifically speaking, yes—it produces altered states of consciousness and can facilitate profound shifts in perspective. But unlike traditional psychedelics, it operates through a different neurochemical pathway, and our use of ketamine is firmly rooted in medical science and clinical best practices.
Whether you’re seeking psychedelic therapy, curious about Spravato®, or prefer a more traditional approach like talk therapy or medication management, Klarisana is here to help you find the path that fits your goals—with safety, respect, and compassion.
